Test for Markers of Silent Inflamation

Test for Markers of Silent Inflamation

Over the last several years some sophisticated tests for markers of silent inflammation have been developed. In order of importance, they are:

    The Gold standard test

This test establishes the ratio of arachidonic acid (AA) to eicosapentanoic acid (EPA): (AA/EPA). This ratio alerts you of silent inflammation years or even decades before the development of any chronic or degenerative illness. An ideal AA/EPA ratio is between 1 and 3. Anything above or below represents a risk for all the consequences of silent inflammation that is out of balance. If 1 to 3 is ideal, why 0.5 isn’t better? Remember, balance is the most important thing for your body.  You also need some pro-inflammatory eicosanoids to help your body fight off infectious disease and to repair damaged tissues.

On the other hand, studies prove that for each 1% drop in your AA/EPA ratio, the risk of dying from heart attack is reduced by 2%. Then, ff your AA/EPA ratio is high (>3.0), you are at greater risk of developing a heart attack, getting cancer, developing Alzheimer and more.

The standard risk rating can be represented by the following:


  1-3: Low risk
  3-8: Moderate risk
  9-15: High risk and
  Greater Than 15: Very High Risk.

The AA/EPA ratio is the single most powerful blood test you can take. Barry Sears, Ph.D., researcher and renowned scientist says to scientific community: "I firmly believe that it predicts your likelihood of developing cancer, Alzheimer's and heart disease decades before these diseases manifest themselves.” Unfortunately, there are only a few places that perform this test correctly. In fact, most doctors do not even know about this test or where to get it.  


    Fasting insulin levels also help quantify your level of silent inflammation.

Fasting insulin levels also helps quantify your level of silent inflammation. This is a straightforward test that can be performed in nearly every medical laboratory.

A good fasting insulin level is anything < 10 uIU/ml and an ideal level is 5.0 uIU/ml. Higher fasting insulin levels, mean more inflammation produced by your body. This is due to the process of insulin stimulation of the production of arachidonic acid (AA) from omega-6 fatty acids (in particular DGLA: dihydro-gamma-linolenic acid). AA is the most powerful pro-inflammatory molecule in your body, it generates both COX (Cyclo-oxygenase) and LOX (Lipo-oxygenase) pro-inflammatory eicosanoids.
An interesting fact is that if you have high cholesterol, you are only 2 times as likely to develop a heart attack, while studies show that if your fasting insulin level is > 10 uIU/ml, you are 5 times as likely to develop heart disease

    Triglyceride/HDL Ratio is a secondary biomarker for silent inflammation.

This test is a secondary biomarker for silent inflammation. You have increased silent inflammation if your level of fasting triglycerides (TG) divided by your good cholesterol (HDL) is greater than 2.
A 2001 study proved that even if they smoked, were sedentary, had high LDL (bad) cholesterol or high blood pressure, those with a TG/HDL ratio < 2 had half the risk of developing a heart disease compared with those with a TG/HDL ratio greater than.

    Highly Sensitive C-Reactive Protein (hsCRP) is currently the most "popular" and well known test for silent inflammation.

This is presently the most "popular" and well known test for silent inflammation.. Originally, hsCRP was an exciting marker, even making the cover of TIME magazine. In fact, some studies showed that elevated hsCRP was a better predictor of heart disease risk than high cholesterol levels.

However, it's not that great a test for silent inflammation. Recent studies have denied the initial findings, mainly because many other things can increase your hsCRP level. In addition, there is no proof that lowering your hsCRP level will really reduce silent inflammatio. Take aspirin as an example. It is a great anti-inflammatory drug, but it will not lower hsCRP levels. Vitamin E will lower the hsCRP level, but it does not significantly decrease inflammation or prevent cardiovascular mortality.

Regardless of the issues mentioned, the hsCRP still offers some measure of silent inflammation and if that motivates you to live a healthier lifestyle, it's worth taking it. A hsCRP between 1 and 3 is considered "average risk", while levels < 1 are ideal. Finally, even if you have normal cholesterol levels hsCRP levels > 3 dramatically increase your risk of heart disease.


Body Fat or Waist Measurement provide an indirect assessment of silent inflammation, because they reflect insulin levels.


Body fat reflects insulin levels; therefore this measurement provides an indirect assessment of silent inflammation. 

For men, ideal body fat measurements are between12% and 15% body fat. waist measurements >40 inches indicate a significant risk for heart disease and insulin resistance. In the case of women, 20 to 25% body fat is the ideal measurement, while results >35 inches indicates a high risk.


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