Celiac Testing in Stuart
    Food Sensitivity Testing

Celiac Testing


Celiac disease tests are primarily used to help diagnose and monitor celiac disease. They are usually ordered on people with symptoms suggesting celiac disease, including anemia and abdominal pain.
Sometimes celiac testing is ordered to screen for asymptomatic celiac disease in those who have close relatives with the disease, as about 10% of them have or will develop celiac disease. Testing may also be ordered in those who have other autoimmune diseases.

Bloating, gas, diarrhea, constipation, new sensitivities to commonly eaten foods Fatigue, headache, depression, irritability, disorientation, dizziness, inability to concentrate Sugar cravings, sensitivities to chemicals and perfumes, alcohol intolerance, increased susceptibility to the side effects of medications
The endomysial antibody (EMA) test detects essentially the same thing as anti-tTG but is less frequently ordered.
Sometimes a total immunoglobulin A (IgA) test is ordered along with or following an anti-tTG test to detect IgA deficiency. If IgA deficiency is present, then an anti-tTG, IgG class may be ordered.
Sometimes an anti-gliadin antibody (AGA) test, and rarely an anti-reticulin antibody (ARA) test, may also be ordered.
An anti-DGP, IgA or IgG test may sometimes be ordered with or following an anti-tTG test, especially if anti-tTG is negative. If the anti-DGP test is positive, it may be used to monitor celiac disease.
An anti-F-Actin test may sometimes be ordered if a person has been diagnosed with celiac disease and a doctor wants to evaluate the severity of intestinal damage. If it is positive, it may be used as a monitoring tool.



To confirm a diagnosis of celiac disease, a biopsy of the small intestine is examined to detect damage to the intestiTo confirm a diagnosis of celiac disease, a biopsy of the small intestine is examined to detect damage to the intestinal villi. However, given the invasive nature and cost of a biopsy, antibody tests are often used to identify those individuals with high probability of having celiac disease.Other tests may be ordered to help determine the severity of the disease and the extent of the complications a person may experience, such as malnutrition, malabsorption, and the involvement of other organs. Tests may include:

CBC (complete blood count) to look for anemia
ESR (erythrocyte sedimentation rate) to evaluate inflammation
CRP (C-Reactive protein) to evaluate inflammation
CMP (comprehensive metabolic panel) to determine electrolyte, protein, and calcium levels, and to verify the status of the kidney and liver
Vitamin D and B12 and folate to measure vitamin deficiencies
Iron, iron binding capacity or transferrin, and ferritin to detect iron deficiency
  Stool fat, to help evaluate malabsorption

Since those with celiac disease may also experience conditions such as lactose intolerance, celiac tests may be done in conjunction with other intolerance and allergy testing.

When is it ordered?

Celiac disease tests are ordered when someone has signs and symptoms suggesting celiac disease, malnutrition, and/or malabsorption. The symptoms are often nonspecific and variable, making the disease difficult to spot. The symptoms may, for a time, be mild and go unnoticed and then progressively worsen or occur sporadically. The condition can affect different parts of the body, resulting in a wide range of symptoms such as:

Abdominal pain and distension
Iron-deficiency anemia that does not respond to iron supplements
Bleeding tendency
  Bloody stool
  Bone and joint pain
  Changes in dental enamel
  Fatigue, weakness
  Greasy, foul-smelling stools
  Mouth ulcers
  Weight loss

The tests may be ordered as part of an investigation of anemia, osteoporosis, infertility, or seizures (certain types are linked to celiac disease).

In children, celiac disease tests may be ordered when a child exhibits:

Gastrointestinal symptoms
Delayed development
Short stature
  Failure to thrive

Autoantibody levels should initially be ordered when a person still has gluten in their diet. Positive or indeterminate results will then be confirmed with a biopsy.
One or more antibody tests may be ordered when someone with celiac disease has been on a gluten-free diet for a period of time. This is done to verify that antibody levels have decreased and to verify that the diet has been effective in relieving symptoms and reversing the intestinal lining damage (this is sometimes still confirmed with a second biopsy).

Asymptomatic people may be tested if they have a close relative with celiac disease, but celiac disease testing is not recommended at this time as a screen for the general population. AGA and/or anti-DGP tests may be ordered to help diagnose and monitor celiac disease in children when the anti-tTG test is negative. IgG versions of the celiac disease tests may be ordered when the IgA tests are negative, especially if the person is shown to be IgA deficient.

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